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. 2011 Aug 17;31(33):11894–11904. doi: 10.1523/JNEUROSCI.2190-11.2011

Figure 2.

Figure 2.

TrkB blockade suppresses the synaptosome increases and endogenous dendritic PSD-95 after eye opening. A, When TrkB signaling was suppressed, synaptosomal PSD-95 level as compared to control was neither increased after EO nor enriched compared to whole lysates (WL). B, Immunohistochemistry of PSD-95 in layer 2/3 VC from two different animals implanted with Bph-PP1 Elvax to the left hemisphere and 1NM-PP1 Elvax to the right. After eye opening, the punctate distribution of PSD-95 seen in the TrkB-blocked cortices (1NM) compared to the contralateral Bph-treated cortices show reductions in endogenous, immunostained, PSD-95 puncta but enhanced staining in somata. Dashed lines indicate the pial surface. A dashed square shows the size of the quantified area for total pixel intensity of PSD-95-positive immunolabels. Scale bar, 10 μm.