Table 1.
Physiologic parameters
| Sham | Injured (CCI) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Untreated | GSNO-treated | SIN-1-treated | Untreated (TBI) | GSNO-treated (GSNO) | SIN-1 treated (SIN-1) | |||||||
| Basal | 3 h | Basal | 3 h | Basal | 3 h | Basal | 3 h CCI | Basal | 3 h CCI | Basal | 3 h CCI | |
| Rectal Temp (°C) |
37.3 ± .3 | 37.2 ± .2 | 37.3 ± .2 | 36.9 ± .2 | 37.2 ± .1 | 36.8 ± .4 | 37.3 ± .2 | 36.6 ± .4 | 37.3 ± .3 | 36.7 ± .2 | 37.3 ± .2 | 36.6 ± .3 |
| MABP (mm Hg) | 123 ± 12 | 121 ± 11 | 122 ± 10 | 120 ± 12 | 122 ± 12 | 119 ± 13 | 121 ± 12 | 97 ± 14 | 116 ± 10 | 95 ± 9 | 118 ± 7 | 91 ± 8 |
| HR (beat/min) | 396 ± 32 | 394 ± 31 | 394 ± 32 | 404 ± 35 | 395 ± 31 | 408 ± 29 | 395 ± 30 | 405 ± 25 | 382 ± 27 | 410 ± 40 | 385 ± 24 | 415 ± 30 |
Measurements were performed before CCI (basal) and at 3 hours after CCI or 1 hour after drug administration (50 μg/kg body weight, oral). Data are presented as mean ± SD for n = 5 animals in each group. No significant differences were observed among untreated and treated groups of sham or injured animals. However, animals after CCI showed a trend of decreased MABP in the injured group. Basal, 30 min before CCI; Temp, temperature; MABP, mean arterial blood pressure; HR, heart rate.