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Median endoxifen concentration by genotype group for the generalized estimating equation shown to address the pattern of change over time for the three genotype groups. The intermediate metabolizers (IM) group had a significant increase in endoxifen concentration when compared to the extensive metabolizers (EM) group (P = .0062). The poor metabolizers (PM) group also had a significant pattern of change (P = .0035) when compared to the EM group.
