Figure 3.

Intracellular activity of PknB inhibitors in a bone marrow derived macrophage model. Macrophages were infected with an MOI of 0.5:1 and incubated in the presence of a dilution series of the inhibitors. After 5 days, the macrophages were lysed and the intracellular bacteria enumerated by CFU platings. Data is expressed as percentage survival compared to the untreated control. Inhibitor structures and corresponding in vitro activity against purified protein are shown in Table 1.