Table 3. Frequencies of HLA class II alleles and QFT-IT positive/negative results.
| Allele name | Number of alleles (% [95%CI]) | P * | ||
| Total | IGRA positive | IGRA-negative | ||
| 2n‡ = 1008 | 2n = 930 | 2n = 48 | ||
| HLA-DRB1 | ||||
| 1202 | 337 (33.4 [30.5–36.4]) | 318 (34.2 [31.1–37.3]) | 11 (22.9 [12.0–37.3]) | 0.119 |
| 0901 | 129 (12.8 [10.8–15.0]) | 119 (12.8 [10.7–15.1]) | 6 (12.5 [4.7–25.2]) | >0.999 |
| 0701 | 61 (6.1 [4.7–7.7]) | 44 (4.7 [3.5–6.3]) | 11 (22.9 [12.0–37.3]) | <0.0001 |
| 1502 | 59 (5.9 [4.5–7.5]) | 53 (5.7 [4.3–7.4]) | 5 (10.4 [3.5–22.7]) | 0.198 |
| 0301 | 54 (5.4 [4.0–6.9]) | 49 (5.3 [3.9–6.9]) | 4 (8.3 [2.3–20.0]) | 0.324 |
| 0803 | 53 (5.3 [4.0–6.8]) | 51 (5.5 [4.1–7.1]) | 0 (0.0 [0.0–7.4]) | 0.170 |
| 1001 | 51 (5.1 [3.8–6.6]) | 49 (5.3 [3.9–6.9]) | 2 (4.2 [0.5–14.3]) | >0.999 |
| others | 264 (26.2 [23.5–29.0]) | 247 (26.6 [23.7–29.5]) | 9 (18.8 [8.9–32.6]) | 0.312 |
| HLA-DQB1 | ||||
| 0301 | 383 (38.0 [35.0–41.1]) | 361 (38.8 [35.7–42.0]) | 12 (25.0 [13.6–39.6]) | 0.067 |
| 0303 | 152 (15.1 [12.9–17.4]) | 138 (14.8 [12.6–17.3]) | 9 (18.8 [8.9–32.6]) | 0.414 |
| 0501 | 94 (9.3 [7.6–11.3]) | 87 (9.4 [7.6–11.4]) | 6 (12.5 [4.7–25.2]) | 0.448 |
| 0201 | 92 (9.1 [7.4–11.1]) | 74 (8.0 [6.3–9.9]) | 12 (25.0 [13.6–39.6]) | 0.001 |
| 0502 | 81 (8.0 [6.4–9.9]) | 76 (8.2 [6.5–10.1]) | 3 (6.3 [1.3–17.2]) | >0.999 |
| 0601 | 70 (6.9 [5.5–8.7]) | 68 (7.3 [5.7–9.2]) | 0 (0.0 [0.0–7.4]) | 0.072 |
| 0401 | 42 (4.2 [3.0–5.6]) | 40 (4.3 [3.1–5.8]) | 1 (2.1 [0.1–11.1]) | 0.717 |
| others | 94 (9.3 [7.6–11.3]) | 86 (9.2 [7.5–11.3]) | 5 (10.4 [3.5–22.7]) | 0.797 |
*Comparison was made between QFT-IT-positive and -negative groups. After Bonferroni's correction, P <0.006 was statistically significant, considering the number of comparisons.
‡
Allele number is shown.
HLA: Human leukocyte antigen; QFT-IT: QuantiFERON-TB Gold In-Tube.