Table 2. SLC2A9 involved epistatic pairs and replication.1 .
SNP1 | chr1 | gene1 | SNP2 | chr2 | gene2 | Ppair | Pint | MGC | CROATIAN replication3 | SOCCS replication3 |
rs12130085 | 1 | NFIA | rs737267 | 4 | SLC2A9 | 4.1e-17 (16.38) | 6.6e-09 (8.20)2 | 2 | 0.045 | 0.178 |
rs737267 | 4 | SLC2A9 | rs9316212 | 13 | ESRRAP2 | 6.2e-17 (16.21) | 1.1e-08 (7.97)2 | 2 | 0.048 | 0.238 |
rs733175 | 4 | SLC2A9 | rs1818116 | 5 | (-) | 3.8e-12 (11.43) | 5.5e-08 (7.27) | 7 | 0.130 | 0.227 |
rs733175 | 4 | SLC2A9 | rs137180 | 22 | SEZ6L | 8.0e-11 (10.09) | 2.6e-07 (6.58) | 4 | 0.035 | 0.155 |
: SNP1 (SNP2) – the first (second) SNP name; chr1 (chr2) – the chromosome where SNP1 (SNP2) locates; gene1 (gene2) – symbol of the gene annotated by SNP1 (SNP2); Ppair – P value of the whole pair test (−log10 P value in brackets); Pint – P value of the interaction test (−log10 P value in brackets); MGC – count of number of individuals in the minor joint genotype class; (-): no gene annotation.
: genome-wide significant.
: Best replication including adjacent SNPs: the SLC2A9 SNP is fixed and the other SNP is to replicate as itself or the first or second neighbour.