Table 1.

Kinetic parameters of inhibition of human Lon peptidase activity by DBN93 as determined by global fitting of experimental data using DynaFit. The resultant values are compared to those previously determined for bacterial Lon. Reported errors are s.e.m.

Parameter	Human Lon	S. Typhimurium Lon†
k3 (× 105 M−1s−1)	4.34 ± 0.16	1.0 ± 0.3
k4 (s−1)	0.0597 ± 0.0022	0.022 ± 0.007
Ki (µM)	1.37	0.216
k5 (s−1)	0.0090 ± 0.0004	0.0032 ± 0.0003
k6 (s−1)	0.00014 ± 0.00001	0.00028 ± 0.00002
Ki* (µM)	0.021	0.017

^†Data previously published (23)