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Hypothetical coevolution of M1-like ribozyme and 5′-leader ribozyme. The 5′-leader ribozyme recognizes a specific amino acid and self-charges to the 3′-end of RNA. In this way, specificity to the tRNA is secured by the direct covalent linkage. M1-like ribozyme is co-evolved with the 5′-leader ribozyme, so that the ribozyme domain is cleaved from the tRNA to release the mature aminoacyl-tRNA. LG, leaving group; aa, aminoacyl.
