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(a) Structure of the class I ligase–BL3-6 Fab complex. (a) Fab binds to RNA in the P5 and P7 regions of the ligase. (b) Overlay of our class I ligase structure with the ligase structure solved by Shechner et al. Purple, Shechner structure; green, our structure, with the ligation junction shown in red. All-atom r.m.s.d. = 1.44 Å. Colour coding in (a) matches that in figure 1. Adapted from Koldobskaya et al. [7].
