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. Author manuscript; available in PMC: 2012 Sep 1.

Published in final edited form as: Basic Clin Pharmacol Toxicol. 2011 May 6;109(3):186–194. doi: 10.1111/j.1742-7843.2011.00708.x

Fig. 3 — The effects of piroxicam on changes in (A) cytochrome P450 (CYP) 4A1 protein expression and (B) systemic and renal 20-hydroxyeicosatetraenoic acid (20-HETE) levels measured 4 hr after saline (vehicle) (4 ml/kg, i.p.) or endotoxin (ET) (10 mg/kg, i.p.) injection to Wistar rats. Piroxicam (10 mg/kg, i.p.) given at 1 hr after or saline ET injection. Data are expressed as means ± SEM of 4–8 animals. ^aSignificant difference from the corresponding value seen in rats treated with saline (vehicle) (p < 0.05). ^bSignificant difference from the corresponding value seen in the rats treated with endotoxin (p < 0.05). ^cSignificant difference from the corresponding value seen in the rats treated with vehicle and piroxicam (p < 0.05).

Fig. 3 — The effects of piroxicam on changes in (A) cytochrome P450 (CYP) 4A1 protein expression and (B) systemic and renal 20-hydroxyeicosatetraenoic acid (20-HETE) levels measured 4 hr after saline (vehicle) (4 ml/kg, i.p.) or endotoxin (ET) (10 mg/kg, i.p.) injection to Wistar rats. Piroxicam (10 mg/kg, i.p.) given at 1 hr after or saline ET injection. Data are expressed as means ± SEM of 4–8 animals. ^aSignificant difference from the corresponding value seen in rats treated with saline (vehicle) (p < 0.05). ^bSignificant difference from the corresponding value seen in the rats treated with endotoxin (p < 0.05). ^cSignificant difference from the corresponding value seen in the rats treated with vehicle and piroxicam (p < 0.05).