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. 2011 Aug 18;2011:315640. doi: 10.4061/2011/315640

Figure 2.

Figure 2

The blood glucose and serum insulin concentrations in Ir P1195L/wt mice. (a) The blood glucose concentrations of fasting mutant male and female mice were assessed. All Ir P1195L/wt mice exhibited blood glucose concentrations within the same range as the Ir wt/wt mice (n = 6–10 for each genotype). (b) The serum insulin concentrations were determined in the nonfasting state of 4- and 9-month-old Ir wt/wt and Ir P1195L/wt mice (n = 7 for each genotype). (c) The serum insulin concentrations were determined in the fasting state of 25-month-old Ir wt/wt and Ir P1195L/wt mice (n = 5 for each genotype). The insulin concentrations were significantly increased in both female and male Ir P1195L/wt mice compared with the Ir wt/wt mice. (d, e) The histochemical analyses of the pancreas of Ir P1195L/wt mice. (d) The Ir P1195L/wt male mice exhibited extensive enlargement of the Langerhans islets compared to Ir wt/wt mice. (e) In addition, the size of islets in Ir P1195L/wt female mice was larger than in Ir wt/wt female mice. The scale bars indicate 200 μm. *P < 0.05, **P < 0.005 by Student's t-test.