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. Author manuscript; available in PMC: 2012 Jul 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 May 14;21(14):4358–4362. doi: 10.1016/j.bmcl.2011.05.018

Scheme 3.

Scheme 3

Synthesis of 5-(2,5-dioxoimidazolidin-4-yl)thiophene-2-carboxylic acid. Reagents: (i) hexamethylenetetramine, CF3CO2H, 90 °C, 3 h, 93%; (ii) (NH4)2CO3, KCN, 1:1 EtOH, H2O, 50–60 °C, 3 h, 67%; (iii) LiOH, THF/MeOH (1:1), RT, 48 h, 53%.