Table 1.
Frequency of Mutation and Association with Median Survival.*
| Mutated Gene | No. of Samples (%) | Median Survival (95% CI) | P Value |
|---|---|---|---|
| γr | |||
| All samples | 439 (100) | 1.86 (1.60–2.14) | |
| TET2 | 90 (20.5) | 1.88 (1.26–2.55) | 0.48 |
| ASXL1 | 63 (14.4) | 1.33 (0.96–1.88) | 0.003 |
| RUNX1 | 38 (8.7) | 1.16 (0.77–1.53) | <0.001 |
| TP53 | 33 (7.5) | 0.65 (0.44–1.10) | <0.001 |
| EZH2 | 28 (6.4) | 0.79 (0.67–1.40) | <0.001 |
| NRAS | 16 (3.6) | 1.03 (0.44–1.98) | 0.006 |
| JAK2 | 13 (3.0) | 2.14 (1.02–3.12) | 0.96 |
| ETV6 | 12 (2.7) | 0.83 (0.62–2.29) | 0.04 |
| CBL | 10 (2.3) | 1.52 (0.14–1.71) | 0.02 |
| IDH2 | 9 (2.1) | 1.58 (0.50–2.14) | 0.03 |
| NPM1 | 8 (1.8) | 2.18 (0.59–2.74) | 0.43 |
| IDH1 | 6 (1.4) | 3.30 (0.35–9.52) | 0.52 |
| KRAS | 4 (0.9) | 0.89 (0.36–7.44) | 0.54 |
| GNAS | 3 (0.7) | ||
| PTPN11 | 3 (0.7) | ||
| BRAF | 2 (0.5) | ||
| PTEN | 1 (0.2) | ||
| CDKN2A | 1 (0.2) |
*
Median survival is listed for specific mutations present in at least 4 of the 439 samples (1%). A patient could have multiple mutations. The P values are for median survival in the group of patients with a mutated gene versus the group of patients without a mutation in that gene. CI denotes confidence interval.