Table 2.

Hazard Ratios for Death in a Multivariable Model.^*

Risk Factor	Hazard Ratio (95% CI)	P Value
Age ≥55 yr vs. <55 yr	1.81 (1.20–2.73)	0.004
IPSS risk group
Intermediate-1 vs. low	2.29 (1.69–3.11)	<0.001
Intermediate-2 vs. low	3.45 (2.42–4.91)	<0.001
High vs. low	5.85 (3.63–9.40)	<0.001
Mutational status
TP53 mutation present vs. absent	2.48 (1.60–3.84)	<0.001
EZH2 mutation present vs. absent	2.13 (1.36–3.33)	<0.001
ETV6 mutation present vs. absent	2.04 (1.08–3.86)	0.03
RUNX1 mutation present vs. absent	1.47 (1.01–2.15)	0.047
ASXL1 mutation present vs. absent	1.38 (1.00–1.89)	0.049

^*The model was generated from a stepwise Cox regression model that included the International Prognostic Scoring System (IPSS) risk category (based on the percentage of blasts in bone marrow, the karyotype, and the number of cytopenias [see Table 2 in the Supplementary Appendix]), age, sex, and mutation status for genes that were mutated in 1% or more of the 428 samples for which the IPSS classification was recalculated. Age was included in the analysis as a categorical variable on the basis of a best-split algorithm showing a significant difference in overall survival between patients less than 55 years of age and those 55 years of age or older (see Table 8 in the Supplementary Appendix).