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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Biol Psychiatry. 2011 May 14;70(6):583–592. doi: 10.1016/j.biopsych.2011.03.035

Figure 3. Exploration and novelty seeking is increased in adult rodents after binge cocaine administration in adolescence.

Figure 3

A: Weight curves and treatment schedules for animals undergoing the hole board tasks. B-D: Hole board exploration. E-H: Hole board food search task. B: Novel, repeat, and total entries into unbaited holes during a 5-minute novel exposure to the hole board chamber. C: Distance traveled in the interior and exterior part of the chamber during novel exposure. D: Resting (not ambulating for at least 2 seconds) and ambulatory time spent in the interior part of the chamber or the exterior part of the chamber during novel exposure. I/E is the ratio of interior time over exterior time. E, F: Hole board food search design with baited holes in black. High-contrast shapes were placed on the four walls of the chamber as reference points. Areas of internal and external measurements are shown. E: Holes baited during habituation and acquisition; F: Holes baited during the reversal trial. G: Working memory ratio (novel entries into baited holes / all entries into baited holes) in the hole board food search task. F: Reference memory ratio (all entries into baited holes/total entries into all holes) in the hole board food search task. All data average ± SEM; vehicle n=8; cocaine n=8.