Table 1. Adolescent cocaine exposure leads to downregulation of plasma membrane and synaptic genes in the amygdala.
Microarray analysis revealed a group of 36 genes classified as “synaptic” or “plasma membrane part” that were downregulated in animals that received cocaine during adolescence. Shown are the probe set IDs, gene name, accession number, fold changes, and p-value (based on log2-transformed data). Vehicle n=6; cocaine n=7.
| Probe ID | Gene name | Accession | Fold change |
P value |
|---|---|---|---|---|
| 1370121_at | Add1: adducin 1 (alpha) | NM_016990 | −1.19 | 4.27E-02 |
| 1368534_at | Adra1d: adrenergic receptor, alpha 1d | NM_024483 | 1.71 | 4.62E-02 |
| 1370621_at | Cd3z: CD3 antigen, zeta polypeptide | D13555 | −1.13 | 3.10E-02 |
| 1369559_a_at | Cd47: CD47 antigen (Rh-related antigen,
integrin-associated signal transducer) |
NM_019195 | −1.18 | 2.50E-02 |
| 1369025_at | Cd5: CD5 antigen | NM_019295 | −1.11 | 3.28E-02 |
| 1373102_at | Cdh13: cadherin 13 | BI282750 | −1.19 | 6.45E-03 |
| 1369112_at | Chrm3: cholinergic receptor, muscarinic 3 | M18088 | −1.17 | 4.30E-02 |
| 1373067_at | Ctnnb1: Catenin (cadherin associated protein), beta 1 | AI102738 | −1.18 | 4.84E-02 |
| 1370625_at | Faim2: Fas apoptotic inhibitory molecule 2 | AF044201 | −1.21 | 3.06E-02 |
| 1398246_s_at | Fcgr3: Fc receptor, IgG, low affinity III | NM_053843 | −1.15 | 4.41E-02 |
| 1369267_at | Gabrg3: gamma-aminobutyric acid A receptor, gamma 3 | NM_024370 | −1.25 | 1.85E-02 |
| 1370590_at | Gpsm1: G-protein signalling modulator 1 (AGS3-like) | AF107723 | −1.17 | 4.08E-02 |
| 1377546_at | Gria4: Glutamate receptor, ionotropic, 4 | BF397279 | −1.31 | 1.48E-02 |
| 1371180_a_at | Grm1: glutamate receptor, metabotropic 1 | Y18810 | −1.16 | 4.15E-02 |
| 1378625_at | Grm8: Glutamate receptor, metabotropic 8 | BF392502 | −1.19 | 2.01E-03 |
| 1368783_at | Icos: inducible T-cell co-stimulator | NM_022610 | −1.13 | 4.78E-02 |
| 1368979_at | Kalrn: kalirin, RhoGEF kinase | NM_032062 | −1.11 | 3.53E-02 |
| 1370078_at | Lin7b: lin-7 homolog b (C. elegans) | NM_021758 | −1.13 | 3.10E-03 |
| 1384190_at | Mapk8ip3: mitogen-activated protein kinase 8 interacting protein 3 | BF553848 | −1.17 | 2.53E-02 |
| 1395927_at | Pdzk1: PDZ domain containing 1 | BE116199 | −1.12 | 3.12E-02 |
| 1388966_at | P2ry1: purinergic receptor P2Y, G-protein coupled 2 | BM388250 | −1.13 | 4.61E-02 |
| 1393207_at | Rab35: RAB35, member RAS oncogene family | BF566116 | −1.12 | 4.31E-02 |
| 1369338_at | Robo1: roundabout homolog 1 (Drosophila) | NM_022188 | −1.17 | 4.98E-02 |
| 1369054_at | Rph3a: rabphilin 3A homolog (mouse) | NM_133518 | −1.27 | 2.29E-02 |
| 1368907_at | Scamp5: secretory carrier membrane protein 5 | NM_031726 | −1.14 | 4.45E-03 |
| 1368445_at | Shank1: SH3 and multiple ankyrin repeat domains 1 | BE105448 | −1.17 | 1.32E-02 |
| 1369715_at | Slc6a11: solute carrier family 6, member 11; GABA transporter | M95763 | −1.3 | 5.00E-02 |
| 1387693_a_at | Slc6a9: solute carrier family 6, member 9; glycine transporter | M95413 | −1.3 | 2.49E-02 |
| 1368896_at | Smad7: MAD homolog 7 (Drosophila) | NM_030858 | −1.14 | 1.47E-02 |
| 1381263_at | Slc27a4: solute carrier family 27 (fatty acid transporter), member 4 | H33747 | −1.15 | 4.24E-02 |
| 1370840_at | Stxbp1: syntaxin binding protein 1 | NM_013038 | −1.11 | 7.16E-03 |
| 1369423_at | Syn3: synapsin III | NM_017109 | −1.26 | 1.45E-02 |
| 1387527_at | Syngr1: synaptogyrin 1 | NM_019166 | −1.17 | 4.07E-02 |
| 1370514_a_at | Syt7: synaptotagmin VII | AI713274 | −1.13 | 1.48E-02 |
| 1378407_at | Trim9: tripartite motif-containing 9 | BF401415 | −1.23 | 2.07E-02 |
| 1369330_at | Unc13a: unc-13 homolog A (C. elegans) | NM_022861 | −1.12 | 1.74E-02 |
| 1384158_at | Unc13c: unc-13 homolog C (C. elegans) | AW522416 | −1.2 | 4.86E-02 |
| 1387716_at | Utrn: utrophin | NM_013070 | −1.32 | 2.47E-02 |