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. 2011 Jul 20;141(9):1754–1761. doi: 10.3945/jn.111.141176

FIGURE 4.

FIGURE 4

 Se acts through PPARγ to upregulate the expression of Arg-I and Mrc-1. (A) RAW 264.7 cells were prestimulated with 1 μmol/L rosiglitazone for 2 h, followed by IL-4 (5 mg/L, 20 h) and LPS (1 mg/L, 12 h). (B) Bone marrow-derived macrophages isolated from Se-deficient (Se-D) diet and Se-adequate (Se-A) diet-fed mice were prestimulated with 1 μmol/L GW9662 for 2 h followed by IL-4 (5 mg/L, 20 h) and LPS (1 mg/L, 12 h). (C) RAW 264.7 macrophage cells were cultured with and without Se followed by pretreatment with 1 μmol/L GW9662 for 2 h prior to stimulation with IL-4 (5 mg/L, 20 h) and LPS (0.1 mg/L, 4 h). Values are means ± SEM, n = 3. Within each graph, means without a common letter differ, P < 0.01.