TABLE 1.
SELECTED STUDIES OF MEDIASTINAL AND HILAR LYMPH NODE STAGING WITH ENDOBRONCHIAL ULTRASOUND–TRANSBRONCHIAL NEEDLE ASPIRATION
| Study | Selection Criteria | N | Mean LN Size (mm) | Sensitivity (%) | NPV (%) | Prevalence* (%) |
|---|---|---|---|---|---|---|
| Yasufuku, et al. (30) | LN ≥ 10 mm or clinical suspicion | 108 | 19 (L), 13 (S) | 94.6 | 89.5 | 68.5 |
| Herth, et al. (31) | LN ≥ 10 mm | 502 | 16 | 94.4 | 11.0 | 98.2 |
| Herth, et al. (36) | LN ≤ 10 mm, PET negative | 100 | 7.9 | 88.9 | 98.9 | 9.0 |
| Bauwens, et al. (32) | Any size LN, PET positive | 106 | 14.4 | 95.0 | 90.6 | 57.5 |
| Lee, et al. (39) | LN 5-20 mm | 105 | 15.2 (L), 8.6 (S) | 94.3 | 96.9 | 33.3 |
| Wallace, et al. (94) | Any size LN | 150 | NR | 69.0 | 88.1 | 30.4 |
| Ernst, et al. (40) | LN ≥ 10 mm | 66 | 15.6 | 86.6 | 77.6 | 61.7 |
| Hwangbo, et al. (37) | LN 5-20 mm | 117 | 14.4 (L), 7.9 (S) | 90.0 | 96.7 | 25.6 |
Definition of abbreviations: L = long axis; LN = lymph node; NPV = negative predictive value; NR = not recorded; PET = positron emission tomography; S = short axis.
Studies were selected based on minimum study size of 50 subjects and presentation of sufficient data to calculate sensitivity, NPV, and prevalence. All data calculated based on patient as unit of analysis except for study by Ernst et al. (40), which is presented with lymph node as unit of analysis.
*
Prevalence of lymph nodes with tumor involvement.