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. 2010 Jan 29;43(6):720–730. doi: 10.1165/rcmb.2009-0412OC

Figure 3.

Figure 3.

(A) Postnatal Fisher pups show increased neutrophils in bronchoalveolar lavage (BAL) infiltrates. Inflammatory cell infiltrates were assessed in BAL fluid isolated from rat pups at PN1, 4, 7, and 14. Fisher pups had significantly elevated neutrophils when compared with Lewis pups at PN1, 7, and 14. Compared with BN pups, neutrophils in Fisher pups were significantly elevated at PN1, 4, and 14 (n = 9, PN1, 7, and 14; n = 6, PN4; *P < 0.05, †P < 0.01). (B) Newborn BN pups display goblet cell hyperplasia. Periodic acid–Schiff staining was used to assess goblet cells in trachea of BN, Fisher, and Lewis rats. Few goblet cells were present in normal lung between PN1 and 14. By contrast, trachea of naive BN rats had significantly elevated goblet cell numbers at PN1. By contrast, trachea of naive BN rats displayed both accumulation and hypertrophy of goblet cells at PN1.