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Redox pathways involved in maintaining the cofactors necessary for the activity of GPx-1. GPx-1 reductively inactivates hydrogen peroxide and lipid hydroperoxides at the expense of GSH, which is oxidized to form GSSG. The enzyme glutathione reductase (GR) recycles GSSG to GSH using NADPH as a source of reducing equivalents, and glucose-6-phosphate dehydrogenase (G6PD) maintains cellular stores of NADPH.
