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High-fat diet (HD) for 8 weeks induced type-2 diabetes model in mice. (A) Body weight. (B) Fasting plasma glucose. (C) Fasting plasma insulin determined by enzyme-linked immunosorbent assay. (D) Fasting Homeostatic Model Assessment (HOMA) score calculated by fasting plasma glucose and insulin. n = 10–13 mice per group. *p < 0.05, **p < 0.01 versus normal diet (ND) mice at the same time point.
