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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Int J Antimicrob Agents. 2011 Jul 5;38(3):217–225. doi: 10.1016/j.ijantimicag.2011.05.004

Table 2.

Diverse biological activities of peptide mimetics

Activity Example Reference(s)
Antimicrobial activity
  Peptoids Peptoid 1-C134mer is active against Mycobacterium bovis bacille Calmette–Guérin and Mycobacterium tuberculosis, and peptoid 1 and 1-C134mer are active against Pseudomonas aeruginosa biofilms. Ndec-16mer and Ntridec-14mer are active against Escherichia coli, Bacillus subtilis and Candida albicans [16,32–34]
  Oligo-acyl-lysine (OAK) derivatives C12K-7α8 is active in vitro and in vivo against Gram-negative bacteria, with no haemolytic activity [35]
NC12-2 β12 exerts potent activity against Gram-positive bacteria whilst exhibiting negligible haemolytic activity [36]
  Phenylalkyne and arylamide compounds Potent antifungal activity against Candida spp. both in planktonic and biofilm forms as well as in the presence of saliva [37]
  Phenylalkyne and arylamide compounds mPE exhibited potent and rapid antimicrobial activity against biofilms of both Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis [38]
Antitumour activity
  Oligo-acyl-lysine (OAK) derivatives α12-3β12 exhibits dose-dependent inhibition of TRAMP-C2, LNCAP, PC3, MCF-7 and N-417 tumour cell lines in vitro and tumour growth in vivo in mice [39]
Anti-inflammatory activity
  Phenylalkyne and arylamide compounds Cell cultures treated with mPE demonstrate dose-dependent inhibition of interleukin (IL)-8 secretion, suggesting mPE is an anti-inflammatory agent, possibly by interfering with NF-κB signal transduction [38]