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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Cardiovasc Imaging Rep. 2011 Feb 1;4(1):63–76. doi: 10.1007/s12410-010-9058-0

Figure 1.

Figure 1

Molecular MRI (echo time, 4 ms) of CM apoptosis in myocardium exposed to mild-moderate injury. A, Mouse injected with AnxCLIO-Cy5.5. B, mouse with a similar degree of injury but injected with the control (annexin-inactivated) agent Inact_CLIOCy5.5. Significant midmyocardial uptake of the active probe (signal hypointensity) is seen in the region of injury (yellow arrows). No significant uptake of the control probe is seen (B). (Reprinted with permission from Sosnovik DE, Garanger E, Aikawa E et al. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circulation Cardiovascular Imaging 2009 November; 2(6):460-7)