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. Author manuscript; available in PMC: 2012 Feb 1.
Published in final edited form as: Curr Cardiovasc Imaging Rep. 2011 Feb 1;4(1):63–76. doi: 10.1007/s12410-010-9058-0

Figure 4.

Figure 4

SPECT imaging of αv integrins. (A) In vivo microSPECT-CT images of 201Tl perfusion (top row, green) and 99mTc-NC100692 (middle row, red) in IGF-1 rat at 4 weeks post-MI were reconstructed in short and horizontal and vertical long axes and fused (bottom row) with a reference contrast CT image (grayscale). All post-MI rats had an anterolateral 201Tl perfusion defect (yellow solid arrows) and focal uptake of 99mTc-NC100692 in defect area. The contrast agent permitted better definition of myocardium allowing differentiation of focal myocardial uptake of targeted radiotracer from uptake within chest wall at the thoracotomy site (dashed yellow arrows). (B) Representative circumferential count profile of middle myocardial section of IGF-1 rat at 4 weeks post-MI. Count profiles for both 99mTc-NC100692 (solid circles) and 201Tl perfusion (open circles) are demonstrated. (Reprinted from Journal of Molecular Cell Cardiology 2010 June; 48(6), Dobrucki LW, Tsutsumi Y, Kalinowski L et al. Analysis of angiogenesis induced by local IGF-1 expression after myocardial infarction using microSPECT-CT imaging.:1071–1079, Copyright(2009), with permission from Elsevier.)