Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
A plausible mechanism of Hcy-induced activation of latent resident MMPs. Hcy-generated oxidative radicals oxidize NO in the catalytic domain active site of the latent MMP generating ONOO−. Generated superoxide and ONOO− can subsequently oxidize cysteine residues within the TIMP, generate nitrotyrosine, and result in the cleavage of TIMPs rendering the MMP active.
