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Homocysteine Autooxidation
| Equation 1: Hcy + Mn+ → M(n−1) + Hcy• |
| Equation 2: M(n−1)+ + O2 → Mn+O2•− |
| Equation 3: Hcy• + Hcy → Hcy-SS-Hcy•− |
| Equation 4: Hcy-SS-Hcy•− + O2 → Hcy-SS-Hcy + O2•− |
Hcy autooxidation is catalyzed by transition metal ions when exposed to plasma leading to the generation of superoxide in reactions 1–4. Hcy-SH, free Hcy; Mn+, transition metal; Hcy•, thiyl radical; Hcy-SS-Hcy•−, Hcy radical intermediate; O2, oxygen; O2•−, superoxide.
