Figure 3.
(a) Normal glycosylated and GPI anchored PrP on the cell surface; (b) pro-PrP on the cell surface using the GPI-PSS as a surrogate transmembrane domain and binds to FLNA just underneath the inner membrane leaflet. The sizes of the PrP and FLNA are not proportional. The size of PrP is approximately corresponding to two FLNA immunoglobulin domains.