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A minimum drawing model on the interplay between pro-PrP, FLNA and integrin β1 in A7 cells. Presence of pro-PrP pulls FLNA closer to the inner membrane leaflet, allowing it to interact with integrin β1. When the level of pro-PrP is reduced, FLNA is retracted from the inner membrane leaflet rendering it unable to bind integrin β1. γ and δ are proteins that are normally associated with either FLNA or integrins.
