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Mean (+SE) of serum bioactive luteinizing hormone (LH; open circles) and testosterone (filled circles) of adult male monkeys (five per group) receiving an implant loaded with the gonadotropin (GnRH) agonist (buserelin) on day 7. On days 0–15 animals were treated, in addition to the GnRH agonist, with GnRH antagonist vehicle (upper panel) or Nal-Glu GnRH antagonist at a dose of 2250 µg/kg daily (bottom panel). ANT, antagonist. (Reproduced with permission from Sharma et al. [1992]).
