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The Homing process. The homing endonuclease (HEase) is expressed from the HEG (red), residing in an intron or as an in-frame domain of an intein (purple) in a hosting gene (cyan). It cleaves the target site (orange) in a vacant homolog of the hosting gene to induce homologous recombination (gene conversion or double crossover), turning the vacant homolog into a HEG-carrying one.
