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. 2011 Jun 22;31(25):9359–9367. doi: 10.1523/JNEUROSCI.6761-10.2011

Figure 6.

Figure 6.

Mutations in the external channel vestibule increase relative kainate efficacy. A, B, Percentage desensitization for glutamate (A) and kainate (B) was calculated relative to maximal responses with desensitization blocked by TCM for GluA1flip or GluA1flip carrying mutations A518S/Y519P or V788I expressed alone or with stargazin (γ2). *Significant effect of stargazin on desensitization, p < 0.05. #Significant difference in glutamate desensitization compared with control GluA1γ2, p < 0.01. C, Kainate efficacy for GluA1flip or GluA1flip carrying mutations A518S/Y519P or V788I expressed alone or with stargazin was calculated relative to maximal glutamate responses with desensitization blocked by TCM. †Significant effect of the mutation on kainate efficacy compared with GluA1flip, p < 0.01, n > 20 cells for GluA1 and GluA1γ2, and n = 7–19 for cells expressing mutated AMPA receptors. *Significant effect of stargazin on kainate efficacy, p < 0.05. D, Representative responses to glutamate and kainate in the absence (solid black line) and presence (dashed blue line) of TCM are overlaid. The blue bar indicates application of TCM and the black bar agonist application.