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. 2011 Jun 26;2(6):115–118. doi: 10.4331/wjbc.v2.i6.115

Figure 2.

Figure 2

Pre-B-cell-receptor signaling is regulated by a feed-back loop via Ikaros and Aiolos. The pre-B-cell-receptor (pre-BCR)-signaling cascade also involves FOXO transcription factors which may act as an interface between early B-cell development and FLT3-signaling that is frequently altered in acute myeloid leukemia (AML)[25]. FOXO-proteins are also regulated by downstream signaling of BCR-ABL1[27]. Disruption of Ikaros function by either deletions or protein interactions may interrupt the inhibitory feed-back loop to the pre-BCR pathway and thereby enhance pre-BCR-signaling.