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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Curr Opin Hematol. 2011 May;18(3):171–176. doi: 10.1097/MOH.0b013e328345a180

Figure 1. miR-132 regulation of p120RasGAP as an angiogenic switch for tumorigenesis.

Figure 1

Tumors secrete growth factors that trigger phosphorylation of CREB and subsequent transcription of miR-132. miR-132 downregulates p120RasGAP thereby removing the endogenous brake on Ras activity and activates quiescent endothelium. Inhibition of miR-132 with an anti-miR restores p120RasGAP expression and dampens endothelial activation to inhibit angiogenesis and tumor growth.