Table 1.
Test battery applied with 20 inbred strains; half of mice received ethanol on days 2 and 5
| Day | Dose | Task | Parameters |
|---|---|---|---|
| 1 | none | Balance beam (BB) | 2 pretraining trials from each end |
| 1 | none | Fixed speed rotarod (FSRR) | 4 pretraining trials at 6.5 RPM |
| 1 | none | Accelerating rotarod (ARR) | 10 training trials at 20 RPM/min |
| 2 | 1.25 g/kg | FSRR | 1 (5 min limit) trial 1 min after injection |
| 2 | 1.25 g/kg | BB | 1 trial 10 min after injection |
| 2 | 1.25 g/kg | ARR | 3 trials 30 min after injection |
| 5 | 1.75 g/kg | Open field (ACT) | 1 5 min trial 5 min after injection |
| 5 | 1.75 g/kg | Grip strength (GRIP) | 3 trials 10 min after injection |
| 5 | 1.75 g/kg | FSRR | 1 (3 min limit) trial 30 min after inject. |
| 5 | 1.75 g/kg | ARR | 3 trials 33 min after injection |
| 8 | 3.0 g/kg to all mice |
Observer-rated ataxia (ORA) | 1 min Baseline period and 1 min period at 10 min after injection |
| 8 | 3.0 g/kg to all mice |
Hypothermia test (HTT) | Into chamber for 2h, then rectal temperature 0, 30, 120 min after inject. |