Table III.

List of intracochlear delivery approaches and their perceived advantages and disadvantages.

Delivery Method	Advantages	Disadvantages
Osmotic Pumps	Flexible Payload Small No Power Required	Cannot turn off or alter profile Limited delivery duration
Direct Injection	Simple Already demonstrated clinically	Single administration Poor control over distribution
Micro-Injector	Simple Already demonstrated clinically Range of infusion rates possible	Challenging surgically Issues with robustness Component-level approach Prone to fouling Poor distribution kinetics
Infusion with Canalostomy	Provides superior distribution kinetics	Multiple surgical sites
Reciprocating System	Wide range of operating conditions May reduce fouling Capable of timed-sequence delivery	Issues with robustness Complex mechanism
Cochlear Implant Mediated Delivery	Integrated with well-established therapy Enhances clinical benefit of implant	Limits therapy to more severely impaired patients May involve complications due to interactions between implant operation and delivery device