Table 3.

Unadjusted and adjusted associations of serum cystatin C-based GFR with extra-renal factors

Variable	Unadjusted % change in eGFRCYSC (95% CI)	P-value	Unadjusted % change in eGFRCYSC (95% CI)	P-value
Age, per 10-y increase	−4.23 (−4.99, −3.47)	<0.001	−3.76 (−4.69, −2.82)	<0.001
Black vs. non-black	2.57 (0.89, 4.28)	0.003	2.62 (0.76, 4.51)	0.006
History of clinical AIDS	−7.55 (−10.12, −5.33)	<0.001	−3.50 (−5.88, −1.05)	0.005
History of hypertension	−3.98 (−5.73, −2.22)	<0.001	−1.01 (−2.91, 0.92)	0.30
Hepatitis C infected vs. uninfected	−3.37 (−4.72, −2.00)	<0.001	−2.22 (−3.62, −0.84)	0.002
Use of ACEi or ARB vs. neither	−8.51 (−10.53, −6.44)	<0.001	−2.22 (−4.81, 0.45)	0.10
CD4 cell count, per 100 cells/mm3	0.57 (0.25, 0.89)	<0.001	0.14 (−0.18, 0.46)	0.40
HIV-1 RNA, per 1-log increase	−1.53 (−2.22, −0.84)	<0.001	−1.84 (−2.56, −1.11)	<0.001
C-reactive protein, per 1mg/L increase	−0.25 (−0.40, −0.09)	0.001	−0.09 (−0.22, 0.04)	0.21
Serum albumin, per 1 g/dL increase	5.70 (3.35, 8.10)	<0.001	1.69 (−0.73, 4.19)	0.17
AST, per 100 U/L increase	−0.03 (−0.06, −0.01)	0.005	3.54 (−0.50, 7.75)	0.09
ALT, per 100 U/L increase	−0.03 (−0.05, <0.01)	0.04	−2.71 (−6.61, 1.36)	0.19
Alkaline phosphatase, per 100 U/L increase	−0.07 (−0.09, −0.04)	<0.001	−3.92 (−6.38, −1.39)	0.003
Proteinuria, per 100 mg/g increase	−0.01 (−0.02, −0.01)	<0.001	−0.92 (−1.18, −0.65)	<0.001

Abbreviations: eGFR_CYSC, serum cystatin C-based estimated glomerular filtration rate; ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; AST, aspartate aminotransferase; ALT, alanine transaminase