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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Immunol. 2011 Jul 22;187(5):2626–2631. doi: 10.4049/jimmunol.1003930

Fig.1. Extracellular histones trigger TLR2 and TLR4 signaling.

Fig.1

(a) TNFα, IL-6, KC and IL-10 levels in wild type, TLR2 KO or TLR4 KO mouse plasma collected 2 h after an intravenous injection of calf thymus histones (25 mg per kg body weight). Data from 5 experiments. (b) Reporter gene expression levels in TLR2 or TLR4 transfected HEK293 cells stimulated with calf thymus histones at the indicated concentrations. The results shown are the means ± SD performed in triplicate. (c) Reporter gene expression levels in TLR2 or TLR4 transfected HEK293 cells stimulated with calf thymus histones (50 µg/ml) and calf thymus DNA at the indicated concentrations. The results shown are the means ± SD performed in triplicate.