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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Brain Res. 2011 Jul 26;1412:44–54. doi: 10.1016/j.brainres.2011.07.031

Figure 4.

Figure 4

Effect of rimonabant pretreatment on the antinociceptive effect of WIN 55,212-2 in rats with a spinal cord injury. Rats were pretreated with either rimonabant or vehicle (Veh). Thirty min later, rats were injected with either WIN 55,212-2 (WIN) or vehicle and tested 30 min thereafter. The four groups are (pretreatment/post-treatment): Veh/Veh; Veh/WIN; Rimonabant/Veh and Rimonabant/WIN. A. Intrathecal pretreatment with 64.7 nmol rimonabant blocked the antinociceptive effect of 57.4 nmol WIN 55,212-2. B. Subcutaneous pretreatment with 6.5 µmol/kg (s.c.) rimonabant blocked the antinociceptive effect of i.c.v 19.1 nmol WIN 55,212-2. Data are expressed as mean ± S.E.M. N = 6/group. * p < 0.05 vs. Veh/Veh, #p < 0.05 vs. Veh/WIN 55,212-2.