Skip to main content
. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Immunol. 2011 Jul 25;187(5):2233–2243. doi: 10.4049/jimmunol.1101233

Figure 2.

Figure 2

Functional analysis of predicted targets of upregulated miRNAs reveals networks associated with immunity, cell survival, and proliferation. (A) Top 30 overrepresented canonical pathways for downregulated gene targets of upregulated miRNAs. Pathways are sorted by score (−log [multiple testing corrected p-value]). A higher score indicates that the pathway is more significantly associated with genes of interest. The line represents statistically significant threshold limit. (B) Significantly overrepresented canonical pathways for non-target differentially expressed genes 0vs48 hours. (C) Top direct interaction network representing 21 downregulated target focus genes, overlaid with predicted major miRNA targeting and functions associated with nodal genes.