Table III.

miRNA processing machinery genes detected at 48 hours post activation

Gene#	Definition	Function	Fold change T48 vs T0	miRNAs
XPO5	Exportin-5	Mediates the nuclear export of microRNA precursors.	4.30	miR-218 miR-24
RANGAP1	Ran GTPase-activating protein 1	mRNA processing and transport	1.60	ND
EIF2C2/AGO2	Protein argonaute-2	Provides endonuclease activity to RNA- induced silencing complexes (RISC). Cleaves siRNA/mRNA heteroduplexes bound to RISC.	3.84	ND
SIP1/GEMIN2	Survival of motor neuron protein- interacting protein 1	Core component of the survival of motor neuron (SMN) complex, which plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.	2.23	ND
GEMIN4	Gem-associated protein 4	Component of the SMN complex, which is required for pre-mRNA splicing in the nucleus.	1.59	miR-155
GEMIN5	Gem-associated protein 5	Component of the SMN complex, which is required for pre-mRNA splicing in the nucleus.	2.13	ND
GEMIN6	Gem-associated protein 6	Component of the SMN complex, which is required for pre-mRNA splicing in the nucleus.	2.11	ND
GEMIN7	Gem-associated protein 7	Component of the SMN complex, which is required for pre-mRNA splicing in the nucleus.	1.90	ND
YBX1	Nuclease-sensitive element-binding protein 1	Participates in different steps of mRNA biogenesis, including mRNA transcription, processing, and transport from the nucleus into the cytoplasm, binds to splice sites in pre-mRNA, and regulates splice site selection.	1.53	ND
ADARB1	Double-stranded RNA- specific editase 1	Binds to short interfering RNAs (siRNA) without editing them and suppresses siRNA-mediated RNA interference.	1.50	miR-218

^#The FDR adjusted p values of every gene in this table is <0.007. Shown are genes implicated in miRNA processing/biogenesis that were significantly differentially expressed between 0 and 48 hours, with relative fold changes.

ND = miRNA not detected