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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Exp Cell Res. 2011 Jun 25;317(16):2333–2341. doi: 10.1016/j.yexcr.2011.06.009

Fig. 3. Truncation of C-terminal PDZ binding domain increases Kv1.3 current.

Fig. 3

A) Voltage protocol used to elicit ionic currents in transfected HEK cells. Cells were held at −60 mV, followed by a 20 ms hyperpolarization to −90 mV, and stepped from −70 mV to +50 mV in 10 mV increments. B) Ionic currents evoked by stepped voltages from −70 to + 50 mV are shown. Current traces represent averages of currents from multiple cells. Data from Kv1.3 and Kv1.3-ΔTDV transfected HEK293 cells are shown. C) Steady state current-voltage relationships indicate that currents measured in cells transfected with Kv1.3 were less than those measured in cells transfected with Kv1.3-ΔTDV. (* indicates p < 0.05; Mann-Whitney U). D) Activation curves plotted from the tail currents of Kv1.3 and Kv1.3-ΔTDV cells indicate that the ΔTDV did not affect voltage sensitivity (n ≥ 15; p > 0.05; Mann-Whitney U).