Table 2.
MIC50 and MIC90 values for compounds 1, 2, and the ethyl acetate extract of Gynoxys verrucosa against various strains of methicillin resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), methicillin resistant Staphylococcus epidermidis (MRSE), and methicillin resistant Staphylococcus epidermidis (MSSE).
| Organism | S. aureus (UAMS-1625) | S. aureus (UAMS-1864, ATCC 33593) | S. aureus (UAMS-1865, NRSa 385) | S. (UAMS-1, ATCCb 49230) | S. epidermidis (UAMS-1037, NRSa 101, ATCCd 35984) | S. epidermidis (UAMS-302, O-47c) | |
|---|---|---|---|---|---|---|---|
| Phenotype | MRSA | MRSA | MRSA | MSSA | MRSE | MSSE | |
|
| |||||||
| Source | Brain abscess (Sifri et al., 2007) | Bloodstream | Bloodstream | Osteomyelitis (bone) | Catheter sepsis | Unknown | |
|
| |||||||
| Antibiotic Resistance Profiled | AMP; CIP; ERY; KAN; LVX; NEO; OX; PEN | AMP; CLI; ERY; GM; KAN; OX; PEN; SXT; TET | AMP; CIP; CLI; CZe; ERY; GM; KAN; LVX; OX; PEN; SXT; TET | AMP; PEN | AMP; CIP; CLI; ERY; GM; KAN; LVXe; OX; PEN | AMP; PEN | |
|
| |||||||
| MIC50 (μg/mL) | Extract | 908 | 1460 | 3290 | 980 | 2190 | 1300 |
| 1 | >246 | >246 | >246 | >246 | >246 | >246 | |
| 2 | 49 | 49 | 147 | 98 | 195 | 195 | |
| OX | 36 | 26 | 92 | 3 | 19 | 0.08 | |
| VAN | 2.7 | 3.2 | 4 | 3.2 | 2.8 | 2.3 | |
|
| |||||||
| MIC90 (μg/mL) | 2 | 450 | 280 | 400 | 440 | 680 | 490 |
| OX | 48 | 80 | 132 | 5 | 88 | 0.75 | |
| VAN | 4.9 | 4.7 | 5 | 4.8 | 4.6 | 4.5 | |
NRS: Network for Antibiotic Resistant Staphylococcus aureus
ATCC: American Type Culture Collection
O-47 was kindly provided by the F. Gotz’s collection of clinical isolates from Germany
AMP: Ampicillin; CIP: Ciprofloxacin; CLI: Clindamycin; CZ: Cefazolin; ERY: Erythromycin; GM: Gentamicin; KAN: Kanomycin; LVX: Levofloxacin; NEO: Neomycin; OX: Oxacillin (Methicillin); PEN: Penicillin; SXT: Sulfamethoxazole/Trimethroprim; TET: Tetracycline; VAN: Vancomycin
Intermediate resistance