Table 3.
Association of time-averaged serum albumin and all-cause, CV, and infection-related mortality in PD patients
Time-averaged serum albumin (g/dl) |
HR (95% CI) | Adjusted HR (95% CI) | |
---|---|---|---|
All-Cause Mortality | CV Mortality | Infection-Related Mortality | |
< 3.0 | 5.80 (4.88–6.89) | 6.23 (4.67–8.31) | 7.16 (4.60–11.15) |
3.00 – 3.19 | 4.40 (3.70–5.23) | 4.83 (3.62–6.44) | 5.34 (3.42–8.33) |
3.20 – 3.39 | 3.21 (2.72–3.79) | 3.18 (2.40–4.21) | 3.89 (2.53–5.97) |
3.40 – 3.59 | 2.45 (2.07–2.88) | 2.79 (2.12–3.68) | 2.45 (1.59–3.77) |
3.60 – 3.79 | 1.83 (1.55–2.16) | 2.07 (1.57–2.73) | 1.54 (0.98–2.39) |
3.80 – 3.99 | 1.37 (1.15–1.64) | 1.34 (0.99–1.81) | 1.44 (0.91–2.28) |
4.00 – 4.19 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
≥ 4.19 | 0.86 (0.63-1.17) | 1.04 (0.64–1.71) | 0.81 (0.37–1.81) |
Using 12,171 PD patients with time-averaged serum albumin between 4.00 and 4.19 g/dl as the reference group. Data adjusted for albumin category by modality, quarter of entry into study cohort, age, gender, race and/or ethnicity, diabetes, dialysis vintage, primary insurance, marital status, ischemic heart disease, congestive heart failure, myocardial infarction, cardiac arrest, pericarditis, cardiac dysrythmia, cerebrovascular disease, peripheral vascular disease, current smoking, body mass index, serum total iron binding capacity, ferritin, creatinine, calcium, phosphorus, parathyroid hormone, alkaline phosphatase, hemoglobin, white blood cell count, and % lymphocyte
CV, cardiovascular; HR, hazard ratio; CI, confidence interval; PD, peritoneal dialysis.