Table 4.
Baseline characteristics and outcomes of PD patients categorized by the magnitude of change in serum albumin over the first six months
| Increase in serum albumin | Unchanged | Decrease in serum albumin | |||||
|---|---|---|---|---|---|---|---|
| ≥0.3 g/dL (n=1356) |
0.2–0.3 g/dL (n=1013) |
0.1–0.2 g/dL (n=1408) |
+0.1 to −0.1 g/dL (n=3221) |
0.1–0.2 g/dL (n=1177) |
0.2–0.3 g/dL (n=860) |
≥0.3 g/dL (n=1288) |
|
| Age (years) | 51 ± 17 | 54 ± 16 | 55 ± 16 | 54 ± 16 | 55 ± 16 | 54 ± 16 | 54 ± 17 |
| Age >65 years | 23 | 28 | 29 | 27 | 30 | 27 | 31 |
| women | 45 | 43 | 47 | 49 | 48 | 48 | 50 |
| Diabetes mellitus | 38 | 41 | 37 | 36 | 37 | 36 | 40 |
| Race and/or ethnicity | |||||||
| Caucasians | 47 | 52 | 52 | 51 | 53 | 53 | 55 |
| Blacks | 25 | 24 | 21 | 23 | 24 | 24 | 23 |
| Hispanics | 16 | 14 | 15 | 14 | 12 | 13 | 12 |
| Others | 12 | 10 | 12 | 12 | 12 | 10 | 10 |
| Dialysis Vintage (mos) | 2 (1, 8) | 2 (1, 10) | 3 (1, 18) | 3 (2, 23) | 3 (1, 21) | 3 (1, 20) | 2 (1, 16) |
| Primary Insurance | |||||||
| Medicare | 55 | 56 | 60 | 60 | 60 | 60 | 60 |
| Medicaid | 6 | 4 | 4 | 4 | 3 | 4 | 5 |
| Others | 39 | 41 | 37 | 36 | 37 | 36 | 35 |
| Co-Morbidities | |||||||
| IHD | 12 | 12 | 15 | 14 | 16 | 13 | 16 |
| CHF | 15 | 18 | 17 | 16 | 19 | 18 | 19 |
| MI | 5 | 4 | 4 | 6 | 6 | 6 | 7 |
| Cardiac arrest | 0.3 | 0.1 | 0.2 | 0.7 | 0.3 | 0.9 | 0.4 |
| Pericarditis | 0.8 | 0.3 | 0.2 | 0.6 | 0.5 | 0.5 | 0.4 |
| Cardiac dysrythmia | 2 | 3 | 4 | 3 | 2 | 4 | 3 |
| CBVD | 4 | 6 | 5 | 5 | 4 | 5 | 6 |
| PVD | 7 | 7 | 8 | 7 | 7 | 8 | 11 |
| COPD | 4 | 4 | 3 | 3 | 4 | 4 | 5 |
| Current smokers | 5 | 7 | 5 | 5 | 6 | 5 | 6 |
| Weight (kg) | 74 ± 19 | 79 ± 20 | 76 ± 20 | 79 ± 21 | 79 ± 20 | 77 ± 20 | 72 ± 19 |
| BMI (kg/m2) | 27 ± 7 | 27 ± 7 | 27 ± 6 | 27 ± 7 | 27 ± 8 | 27 ± 8 | 27 ± 7 |
| Serum albumin (g/dl) | 3.3 ± 0.5 | 3.5 ± 0.5 | 3.6 ± 0.4 | 3.7 ± 0.4 | 3.7 ± 0.4 | 3.8 ± 0.4 | 3.8 ± 0.5 |
| Creatinine (mg/dl) | 8.4 ± 3.8 | 8.2 ± 3.6 | 8.3 ± 3.7 | 8.7 ± 3.9 | 8.8 ± 3.9 | 8.7 ± 3.9 | 8.4 ± 3.7 |
| Ferritin (ng/ml) | 270 (116, 526) |
250 (112, 483) |
227 (113, 457) |
250 (108, 511) |
233 (105, 482) |
240 (114,4 85) |
252 (116, 513) |
| TIBC (mg/dl) | 222 ± 52 | 236 ± 50 | 238 ± 48 | 240 ± 49 | 244 ± 50 | 242 ± 50 | 238 ± 48 |
| Calcium (mg/dl) | 9.0 ± 0.8 | 9.1 ± 0.7 | 9.2 ± 0.7 | 9.2 ± 0.8 | 9.3 ± 0.8 | 9.3 ± 0.8 | 9.3 ± 0.8 |
| Phosphorus (mg/dl) | 5.4 ± 1.5 | 5.3 ± 1.4 | 5.3 ± 1.4 | 5.4 ± 1.4 | 5.4 ± 1.4 | 5.4 ± 1.4 | 5.5 ± 1.5 |
| PTH (pg/ml) | 283 (162, 493) |
274 (154, 471) |
282 (150, 505) |
291 (160, 535) |
285 (159, 503) |
278 (152, 530) |
294 (162, 567) |
| Alkaline phosphatase (U/L) |
117 ± 90 | 113 ± 77 | 113 ± 82 | 115 ± 92 | 109 ± 68 | 113 ± 81 | 118 ± 81 |
| Hemoglobin (g/dl) | 11.7 ± 1.7 | 12.1 ± 1.4 | 12.1 ± 1.4 | 12.2 ± 1.5 | 12.4 ± 1.5 | 12.4 ± 1.5 | 12.2 ± 1.5 |
| WBC count (X 103/µL) | 7.7 ± 3.0 | 7.6 ± 2.3 | 7.5 ± 2.5 | 7.5 ± 2.4 | 7.7 ± 2.3 | 7.6 ± 2.4 | 7.7 ± 3.2 |
| % Lymphocyte count | 19 ± 8 | 20 ± 8 | 20 ± 8 | 20 ± 8 | 20 ± 8 | 20 ± 8 | 19 ± 8 |
| Mortality | 35 | 42 | 40 | 39 | 39 | 39 | 46 |
Categorical variables are given as percentage; continuous variables as mean +/− SD or median (25th, 75th percentile).
COPD, chronic obstructive pulmonary disease; CHF, Congestive heart failure; IHD, schemic heart disease; MI, myocardial infarction; PVD, peripheral vascular disease; BMI, body mass index; PTH, parathyroid hormone; CBVD, cerebrovascular disease; PD, peritoneal dialysis; HD, hemodialysis; TIBC, total iron-binding capacity; WBC, white blood cells
Conversion factors for units: albumin and hemoglobin in g/dL to g/L, x10; creatinine in mg/dL to umol/L, x88.4; calcium in mg/dL to mmol/L, x0.2495; phosphorus in mg/dL to mmol/L, x0.3229.
No conversion necessary for ferritin in ng/mL and ug/L, PTH in pg/mL and ng/L, and WBC count in 10^3/uL and 10^9/L