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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: J Immunol. 2011 Jul 20;187(5):2310–2321. doi: 10.4049/jimmunol.1100363

Figure 7. Memory CD8 T cells require a reduced period of antigenic stimulation for optimal expansion.

Figure 7

Mice were immunized with 1×105 VSV-OVA-NJ 60 days prior to secondary challenge with 1×105 VSV-OVA-Ind and treated with 500ug of 25-D1.16 mAb at the time of infection (D0) or at 24 hour intervals after the secondary challenge (D1-D4). Control mice (Ig Control) were treated with 500ug of mouse IgG1 mAb. Memory indicates the population of Ova-tet+ cells from mice that only received primary infection. Five days after secondary infection, Ova-tetramer positive CD8 T cells from the spleen and lung were assessed via flow cytometry. Graphs represent the mean +/− SEM from 4–5 mice per group of Ova-tetramer positive cells as a percentage of the entire CD8 T cell population. Representative data from two independent experiments. *, p < 0.01.