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. Author manuscript; available in PMC: 2012 Sep 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Jul 19;21(18):5320–5323. doi: 10.1016/j.bmcl.2011.07.024

Table 1.

Worm burden reductions in adult F. hepatica harbored in rats following the administration of dispiro peroxides at single oral doses of 100 mg/kg.

graphic file with name nihms313036t1.jpg
Compd X Y Worm Burden
Reduction (%)		 Curesa
Control ------ ------ ------ 0/12
ASb ------ ------ 30 2/5
1ac O CH2COOH 100e 10/10
1b OCH2 CH2COOH 100e 3/3
1c OO CH2COOH 100e 4/4
1d CH2O CH2COOH 0 0/3
2a O COOH 52 0/4
2b OCH2 COOH 61e 1/3
2c OO COOH 100e 4/4
3ad O CH2COOH 0 0/3
3b OCH2 CH2COOH 95e 2/3
3c OO CH2COOH 29 0/3
4a O COOH 26 0/3
4b OCH2 COOH 100e 3/3
4c OO COOH 100e 3/3
5a O ------ 100e 3/3
5b OCH2 ------ 100e 3/3
5c OO ------ 92e 2/4
a

cures = number of rats cured/number of rats treated

b

AS = artesunate

c

data from Keiser et al.8

d

data from Zhao et al.10

e

p < 0.05 from the Kruskal-Wallis test comparing the median values of the responses between the treatment and control groups