. Author manuscript; available in PMC: 2012 Sep 15.

Published in final edited form as: Bioorg Med Chem Lett. 2011 Jul 19;21(18):5320–5323. doi: 10.1016/j.bmcl.2011.07.024

Table 2.

Worm burden reductions in adult F. hepatica harbored in rats following the administration of selected dispiro peroxides at single oral doses of 50 and 25 mg/kg.

Compd	Dose (mg/kg)	Worm Burden Reduction (%)	Cures
Control	------	------	0/12
1a^a	50	53	2/4
1b^b	50	100^c	4/4
1b^b	25	88^c	3/4
1c^b	50	100^c	4/4
1c^b	25	71^c	0/4
2c	50	48	1/4
4b	50	71^c	0/4
4c^b	50	61^c	1/4
5a	50	19	0/4
5b^b	50	100^c	3/3
5b^b	25	0	1/4

data from Zhao et al.¹⁰

data from Kirchhofer et al.³¹

p < 0.05 from the Kruskal-Wallis test comparing the median values of the responses between the treatment and control groups