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. 2011 Jun;25(6):2001–2011. doi: 10.1096/fj.10-177378

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/us/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — End-tidal gas control, ventilation, and pulmonary arterial systolic pressure during mild and moderate hypoxia. A, B) P_ETo₂ and P_ETco₂ in mild hypoxia (A) and moderate hypoxia (B). P_ETo₂ was well matched between groups. P_ETco₂ was lower for the HIF2 patients, reflecting their lower baseline air-breathing P_ETco₂. C, D) Ventilation, given at body temperature and pressure, saturated with water vapor, in mild (C) and moderate hypoxia (D). Baseline ventilation and the increase in ventilation provoked by hypoxia were not significantly different between the two groups. E, F) Pulmonary arterial systolic pressure. Compared with control participants, HIF2 patients had elevated pulmonary arterial systolic pressures at baseline (24±2 vs. 35±1 mmHg, P<0.003), and increased sensitivity to moderate (F) but not mild (E) hypoxia (5.5±1.3 vs. 11.5±0.7 mmHg, P<0.004). Values are expressed as means ± sd. Horizontal black bars indicate 10-min periods of mild (A, C, E) and moderate (B, D, F) exposures to hypoxia.