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In vivo studies of ABT-737 or etoposide in LX33 primary xenografts (A) or ABT-737, etoposide or combination of ABT-737 and etoposide in LX22 (B) and LX36 (C) primary xenografts. Tumor growth of SCLC primary xenografts on mice treated with vehicle control (blue), ABT-737 (yellow) at 100 mg/kg/d i.p. for 21 d, etoposide (red) at 12 mg/kg/d for days 1, 4, and 9 or ABT-737 plus etoposide (green). X axis, days after the initiation of treatment.
