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. 2011 Jun 21;7:502. doi: 10.1038/msb.2011.36

Figure 9.

Figure 9

dFOXO-bound genes are conserved between the fly and the worm. (A) Overlap between the fly orthologues of the genes that are downregulated by reduced function of daf-2 and upregulated by reduced function of daf-16 in the worm (Murphy et al, 2003), on the one hand, and those downregulated in daGAL4>UAS-dInRDN and upregulated in dfoxoΔ/Δ daGAL4>UAS-dInRDN in the fly, on the other (hypergeometric distribution, P=7 × 10−6). (B) Overlap between the fly orthologues of the genes that are upregulated by reduced function of daf-16 in a daf-2 background in the worm (McElwee et al, 2007), on the one hand, and upregulated in dfoxoΔ/Δ daGAL4>UAS-dInRDN in the fly, on the other (hypergeometric distribution, P<10−15). (C) Overlap between the genes bound by dFOXO in the fly and the fly orthologues of the genes bound by DAF-16 in the worm (Oh et al, 2006; Schuster et al, 2010). (D) Representative functional categories enriched within the overlap shown in (C).